Premium
Effect of gastric acidity on enoxacin absorption
Author(s) -
Lebsack M E,
Nix David,
Ryerson Bruce,
Toothaker Roger D,
Welage Linda,
Norman Allyn M,
Schentag Jerome J,
Sedman Allen J
Publication year - 1992
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1992.138
Subject(s) - enoxacin , ranitidine , pentagastrin , bioavailability , pharmacology , crossover study , pharmacokinetics , oral administration , chemistry , drug interaction , stomach , absorption (acoustics) , medicine , gastric acid , placebo , antibiotics , norfloxacin , biochemistry , physics , alternative medicine , pathology , ciprofloxacin , acoustics
The effect of gastric acidity on the oral absorption of the quinolone antibiotic enoxacin was evaluated in 12 healthy volunteers. In a randomized, crossover design, single 400 mg oral enoxacin doses were administered on four occasions: alone, after 50 mg intravenous ranitidine, after 2 µg/kg subcutaneous pentagastrin, and after combined ranitidine and pentagastrin treatment. Gastric pH was monitored by radiotelemetry capsule for 4 hours after enoxacin administration. Ranitidine pretreatment reduced enoxacin oral bioavailability by an average of 26%. This effect was abolished when pentagastrin was used to maintain low gastric pH. Thus the ranitidine‐induced decrease in enoxacin oral bioavailability probably results from a decrease in gastric acidity rather than from an interaction with ranitidine itself. Clinical Pharmacology and Therapeutics (1992) 52 , 252–256; doi: 10.1038/clpt.1992.138