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The relationship between alfentanil distribution kinetics and cardiac output
Author(s) -
Henthorn Thomas K,
Krejcie Tom C,
Avram Michael J
Publication year - 1992
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1992.129
Subject(s) - alfentanil , indocyanine green , pharmacokinetics , cardiac output , distribution (mathematics) , medicine , anesthesia , metabolic clearance rate , blood flow , chemistry , pharmacology , hemodynamics , cardiology , surgery , mathematics , mathematical analysis , propofol
The relationship between cardiac output and the tissue distribution of alfentanil was investigated in seven healthy volunteers. Subjects were given 10 µg/kg alfentanil and 0.5 mg/kg indocyanine green. Arterial blood samples were obtained at baseline, 1 minute, every ½ minute until 5 minutes, and then every minute until 15 minutes after the drug injection was begun. Subsequent samples were collected to 6 hours. Cardiac output was measured continuously by use of thoracic bioimpedance. Alfentanil pharmacokinetics were modeled with both a standard three‐compartment model and a four‐compartmental model based in part on the two‐compartmental pharmacokinetics of indocyanine green. The sum of intercompartmental clearances for both the three‐ and four‐compartment models were significantly correlated with the measured cardiac outputs, r = 0.93 and r = 0.88, respectively. These findings indicate that the intercompartmental clearance (i.e., tissue distribution) of alfentanil is largely determined by cardiac output (i.e., tissue blood flow). Clinical Pharmacology and Therapeutics (1992) 52, 190–196; doi: 10.1038/clpt.1992.129