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Differential effects of two dihydropyridine calcium antagonists in humans
Author(s) -
Belz Gustav G,
Bliesath Harald,
Essig Jürgen,
Neumann Norbert,
Zech Karl,
Wurst Wilhelm
Publication year - 1992
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1992.104
Subject(s) - nifedipine , inotrope , heart rate , vasodilation , placebo , blood pressure , dihydropyridine , medicine , chronotropic , diastole , clinical pharmacology , pharmacology , anesthesia , cardiology , calcium , alternative medicine , pathology
We studied the effects after single doses of niguldipine (0.3, 0.6, and 0.9 mg intravenously; 8 and 16 mg orally) and nifedipine (2 mg intravenously; 20 mg orally) in healthy male volunteers in randomized placebo‐controlled experiments. Total peripheral resistance (TPR), heart rate—corrected electromechanical systole (QS 2c ), and preelection period (PEP C ) were assessed noninvasively. Both drugs induced a similar pronounced decrease in TPR, indicating peripheral vasodilation, followed by increasing heart rate and cardiac output, a decrease in diastolic blood pressure, and a shortening of the PEP C . QS 2c was unchanged after niguldipine. The prolongation of QS 2c after oral nifedipine is suggestive of a negative inotropic effect. We conclude that the vasodilatory effects of dihydropyridines may (as for nifedipine) or may not (as for niguldipine) be associated with changes that are suggestive of negative inotropic effects, and that this difference is detectable by noninvasive methods in healthy subjects. Clinical Pharmacology and Therapeutics (1992) 52, 68–79; doi: 10.1038/clpt.1992.104