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A controlled trial of the cost benefit of computerized bayesian aminoglycoside administration
Author(s) -
Burton Michael E,
Ash Cynthia L,
Hill Donald P,
Handy TaRee,
Shepherd Marvin D,
Vasko Michael R
Publication year - 1991
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1991.86
Subject(s) - dosing , aminoglycoside , medicine , pharmacokinetics , clinical pharmacology , clinical trial , antibiotics , pharmacology , biology , microbiology and biotechnology
We studied the effect of a bayesian pharmacokinetic dosing program on the outcome of aminoglycoside therapy in patients with clinical infections. Patients were randomized to a control (dosing based on physician choice; n = 75) or experimental group (dosing based on the bayesian program; n = 72). Both groups used serum aminoglycoside concentration data when making dosing decisions. Improved response rates were seen in the experimental (60%; 42/68) compared with the control group (48%; 36/68). A higher, but not statistically significant, incidence of toxicity was found in the control (7/75; 9.7%) versus the experimental group (4/72; 5.1%). Mean length of total hospital stay was significantly longer for patients in the control group (20.3 days) compared with the experimental group (16.0 days) (p = 0.028). The variables from multivariate analysis with a significant impact on length of stay were patient group and length of aminoglycoside therapy. On the basis of a reduced length of stay, a potential cost savings of $1311 per patient can be achieved. Clinical Pharmacology and Therapeutics (1991) 49 , 685–694; doi: 10.1038/clpt.1991.86