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Effect of food on the bioavailability of cyclandelate from commercial capsules
Author(s) -
Kaniwa Nahoko,
Ogata Hiroyasu,
Aoyagi Nobuo,
Ejima Akira,
Takahashi Terutaka,
Uezono Yuko,
Imazato Yuu
Publication year - 1991
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1991.81
Subject(s) - bioavailability , postprandial , capsule , urine , chemistry , pharmacokinetics , metabolite , drug , pharmacology , food science , medicine , biology , insulin , biochemistry , botany
The bioavailability of five capsules of cyclandelate that are commercially available in Japan was determined in ten healthy volunteers by measuring mandelic acid (a main metabolite of cyclandelate) excreted in the urine. Bioinequivalence among the five capsules was demonstrated. The relative cumulative excretion of mandelic acid of the most poorly bioavailable capsule was 38% of the most highly bioavailable capsule. The effect of food on the bioavailability of these two capsules was investigated by use of two different kinds of food, one containing fat and one containing high carbohydrates but very low fat. The bioavailability of the two capsules was increased when subjects consumed both types of food before drug administration, although there was a greater effect on bioavailability with food containing fat. This suggests that the absorption of cyclandelate was incomplete in fasting subjects, even from the capsule with the highest bioavailability. Bioinequivalence between the two capsules remained after postprandial drug administration. Clinical Pharmacology and Therapeutics (1991) 49 , 641–647; doi: 10.1038/clpt.1991.81