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A pharmacodynamic interaction between caffeine and phenylpropanolamine
Author(s) -
Brown Nancy J,
Ryder Diane,
Branch Robert A
Publication year - 1991
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1991.152
Subject(s) - phenylpropanolamine , pharmacodynamics , caffeine , pharmacology , medicine , anesthesia , chemistry , pharmacokinetics
The pharmacokinetic and pharmacodynamic interaction between caffeine and phenylpropanolamine has been investigated in six normal subjects in a double‐blind, placebo‐controlled, Latin‐square design study. After 3 days on a 100 mEq sodium, xanthine‐free diet, fasting subjects were placed in a supine position and were given 25 mg phenylpropanolamine and placebo, 250 mg caffeine and placebo, or 25 mg phenylpropanolamine and 250 mg caffeine in random order. Blood pressure, pulse, plasma renin activity, and plasma catecholamine levels were measured before and for 3 hours after drug administration. Plasma and urinary phenylpropanolamine, caffeine, and caffeine metabolite levels were measured serially for 48 hours. Coadministration of caffeine and phenylpropanolamine produced an additive increase in blood pressure. This effect could not be explained by any pharmacokinetic interaction between the two drugs and occurred even though phenylpropanolamine attenuated the epinephrine and renin response to caffeine. These data suggest that a clinically relevant interaction between caffeine and phenylpropanolamine does occur in drug‐free subjects and that this interaction cannot be explained by a mechanism involving the sympathetic or renin‐angiotensin systems. Clinical Pharmacology and Therapeutics (1991) 50, 363–371; doi: 10.1038/clpt.1991.152