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Pharmacokinetics, pharmacodynamics, and minimum effective clinical dose of intravenous nicardipine
Author(s) -
Cook Eileen,
Clifton G Gil,
Vargas Ramon,
Bienvenu Gregory,
Williams Roger,
Sambol Nancy,
McMahon Gil,
Grandy Susan,
Lai ChiiMing,
Quon Check,
Anderson Catherine R,
Turlapaty Prasad,
Wallin J David
Publication year - 1990
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1990.97
Subject(s) - nicardipine , blood pressure , medicine , pharmacokinetics , pharmacodynamics , heart rate , placebo , anesthesia , mean blood pressure , pharmacology , alternative medicine , pathology
Nicardipine hydrochloride was administered intravenously to two groups of hypertensive patients: one group of 37 patients with mild to moderate hypertension and one group of 20 patients with severe hypertension. In the first group, doses of 0.5, 1, 2, and 4 mg/hr, as well as placebo, were infused for 48 hours in a double‐blind fashion. Blood pressure and heart rate were monitored for this period and for the 24 hours after the infusion was discontinued. Significant decrements in blood pressure were noted with all doses; 4 mg/hr produced lowering that was greater than all other doses; 1 and 2 mg/hr produced lowering that was greater than 0.5 mg/hr but that were not different from each other. Excellent correlation of blood pressure reduction and plasma level was observed and linear kinetics existed. In the severe hypertensive patients, 1, 2, 4, 5, and 8 mg/hr were infused to established minimal and ineffective doses. One milligram per hour was an ineffective dose; 4, 5, and 8 mg/hr all produced significant reductions over the course of the study that were undistinguishable from each other. Two milligrams per hour produced modest reductions in blood pressure. Blood pressure reduction also correlated with plasma levels in the severe hypertensive group. Clinical Pharmacology and Therapeutics (1990) 47 , 706–718; doi: 10.1038/clpt.1990.97