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The pharmacokinetics of teicoplanin in varying degrees of renal function
Author(s) -
Lam Y W Francis,
KapusnikUner Joan E,
Sachdeva Meena,
Hackbarth Corinne,
Gambertoglio John G,
Sande Merle A
Publication year - 1990
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1990.87
Subject(s) - teicoplanin , pharmacokinetics , glycopeptide antibiotic , renal function , medicine , creatinine , urine , pharmacology , nomogram , antibiotics , impaired renal function , clinical pharmacology , urology , chemistry , vancomycin , bacteria , biology , staphylococcus aureus , biochemistry , genetics
The pharmacokinetics of teicoplanin, a new glycopeptide antibiotic with activity against aerobic gram‐positive bacteria, were characterized after intravenous administration of a single 3 mg/kg dose in five healthy volunteers and six patients with various degrees of stable renal insufficiency. Serum and urine samples were collected during a 15‐day period and drug concentrations were assayed microbiologically. The mean elimination half‐life of teicoplanin was 162.6 ± 69.8 hours in healthy volunteers and was prolonged with decreased renal function. The mean plasma and renal clearances of teicoplanin in healthy subjects were 11.4 ± 1.5 ml/min and 10.0 ± 1.0 ml/min, respectively. Both values decreased in patients with renal failure and correlated significantly with measured creatinine clearances ( r 2 = 0.938 and 0.884, respectively). A nomogram for dosage adjustment in patients with varying degrees of renal failure is presented. Clinical Pharmacology and Therapeutics (1990) 47, 655–661; doi: 10.1038/clpt.1990.87