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Novel multivalent effects of pyrazinoylguanidine in patients with azotemia
Author(s) -
Beyer Karl H,
Gelarden R Thomas,
Vary Jeanne E,
Brown Linda E,
Vesell Elliot S
Publication year - 1990
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1990.84
Subject(s) - azotemia , plasma renin activity , urea , aldosterone , endocrinology , medicine , chemistry , excretion , creatinine , renal function , urine , sodium , blood pressure , renin–angiotensin system , biochemistry , organic chemistry
In patients with azotemia, urea excretion, urea clearance, and urea/creatinine clearance ratio were increased by pyrazinoylguanidine in a dose‐related manner. Urine volume and excretion of sodium > chloride > potassium tended to increase during administration of pyrazinoylguanidine. Systemic arterial pressure declined while pyrazinoylguanidine was given at 300 or 600 mg b.i.d. for 3 days. At both doses pyrazinoylguanidine reduced plasma renin activity during the first 2 hours. Between days 1 and 3 only the high dose of pyrazinoylguanidine decreased plasma renin activity and plasma aldosterone levels. These findings with pyrazinoylguanidine are consistent with those of secretion of urea in human subjects across the renal tubules and indicate that this process is susceptible to pharmacologic alteration, even in the presence of severe renal insufficiency. Clinical Pharmacology and Therapeutics (1990) 47, 629–638; doi: 10.1038/clpt.1990.84