Premium
Influence of tretinoin on the percutaneous absorption of minoxidil from an aqueous topical solution
Author(s) -
Ferry James J,
Forbes Kristi K,
VanderLugt James T,
Szpunar Gregory J
Publication year - 1990
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1990.55
Subject(s) - minoxidil , aqueous solution , absorption (acoustics) , chemistry , dermatology , tretinoin , medicine , pharmacology , materials science , retinoic acid , biochemistry , organic chemistry , gene , composite material
Nineteen healthy male volunteers completed a three‐way, randomized, crossover study to determine the effect of the synthetic retinoid, tretinoin, on percutaneous absorption of minoxidil. Subjects received, for 20 days, twice‐daily administrations of 1 ml of an aqueous 2% topical minoxidil solution either alone, with once‐daily applications of a 0.05% tretinoin cream, or with once‐daily applications of a vehicle control cream. When minoxidil was coadministered with tretinoin cream, minoxidil absorption was increased nearly threefold, compared with a 1.3‐fold increase in absorption observed with coadministration of vehicle control cream. Transepidermal water loss measurements, which are sensitive to changes in stratum corneum function, were also significantly increased with tretinoin. No treatment‐related changes in stratum corneum thickness were observed on the basis of skin biopsy analysis. The findings indicate that percutaneous minoxidil absorption is enhanced by tretinoin as a result of increased stratum corneum permeability. Clinical Pharmacology and Therapeutics (1990) 47, 439–446; doi: 10.1038/clpt.1990.55