Premium
Severity of cirrhosis and the relationship of α 1 ‐acid glycoprotein concentration to plasma protein binding of lidocaine
Author(s) -
Barry Michael,
Keeling Paul W N,
Weir Donald,
Feely John
Publication year - 1990
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1990.41
Subject(s) - lidocaine , cirrhosis , glycoprotein , liver disease , orosomucoid , clinical pharmacology , plasma concentration , medicine , plasma protein binding , serum concentration , plasma levels , chemistry , endocrinology , pharmacology , biochemistry , anesthesia
The concentration of α 1 ‐acid glycoprotein, the major determinant of the plasma protein binding of basic drugs, and the extent of lidocaine protein binding was related to the severity of liver disease in 30 cirrhotic patients. In comparison with matched control subjects, α 1 ‐acid glycoprotein concentration (77 ± 7 versus 37 ± 3 mg/dl; mean ± SEM; p < 0.01) and lidocaine binding (69% ± 2% versus 35% ± 2%; p < 0.01) was markedly reduced. There was a significant negative correlation ( r = 0.78; p < 0.01) between free lidocaine and α 1 ‐acid glycoprotein concentration. Furthermore, both were significantly related to the severity of liver disease, as assessed by use of the Child Turcotte classification. Clinical Pharmacology and Therapeutics (1990) 47, 366–370; doi: 10.1038/clpt.1990.41