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Clinical and pharmacokinetic properties of a transdermal nicotine patch
Author(s) -
Mulligan Seamus C,
Masterson Joseph G,
Devane John G,
Kelly John G
Publication year - 1990
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1990.36
Subject(s) - pharmacokinetics , transdermal , nicotine , transdermal patch , medicine , pharmacology
We examined the pharmacokinetics of a transdermal nicotine patch and evaluated the usefulness of such a patch in a pilot smoking‐cessation program. Use of the patch was associated with plasma nicotine concentrations that were comparable to smoking or to the use of other smoking‐cessation devices. However, these plasma concentrations were maintained for 24 hours, and the patch appeared to be suitable for use once a day. Its use in a 6‐week placebo‐controlled double‐blind study resulted in a significant degree of smoking cessation or in reduction of smoking activity. The findings suggest that it may be valuable to extend investigations to a larger population and that transdermal nicotine may have a useful role in smoking‐cessation therapy. Clinical Pharmacology and Therapeutics (1990) 47, 331–337; doi: 10.1038/clpt.1990.36