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Disposition of nicotine and eight metabolites in smokers and nonsmokers: Identification in smokers of two metabolites that are longer lived than cotinine
Author(s) -
Kyerematen Gabriel A,
Morgan Monica L,
Chattopadhyay Balaka,
Bethizy J Donald,
Vesell Elliot S
Publication year - 1990
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1990.208
Subject(s) - cotinine , nicotine , metabolite , urine , pharmacology , chemistry , disposition , clinical pharmacology , cigarette smoke , glucuronide , active metabolite , medicine , biochemistry , psychology , environmental health , social psychology
The disposition of a single intravenous dose of 14 C‐nicotine was investigated in six cigarette smokers and six nonsmokers. Plasma and urinary elimination of both nicotine and cotinine was faster in smokers than in nonsmokers. In the urine of both smokers and nonsmokers, we identified nicotine and eight metabolites, including two new metabolites: metabolite A (3‐hydroxycotinine glucuronide) and metabolite G (demethylcotinine Δ 2′,3′ ‐enamine). Metabolites A and G were of particular interest because, in smokers, they both persisted longer than cotinine. This property renders them more sensitive than cotinine as potential indicators of passive exposure to cigarette smoke. Clinical Pharmacology and Therapeutics (1990) 48 , 641–651; doi: 10.1038/clpt.1990.208