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Hemodynamic effects of different H 2 ‐receptor antagonists
Author(s) -
Hinrichsen Holger,
Halabi Atef,
Kirch Wilhelm
Publication year - 1990
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1990.153
Subject(s) - impedance cardiography , medicine , famotidine , morning , heart rate , ranitidine , placebo , blood pressure , hemodynamics , anesthesia , stroke volume , cimetidine , cardiology , alternative medicine , pathology
In a randomized, placebo‐controlled, double‐blind study, 10 healthy volunteers were treated orally once a day for 1 week each with placebo, 800 mg Cimetidine, 300 mg ranitidine, and 40 mg famotidine. On the seventh treatment day, heart rate, blood pressure, systolic time intervals, and impedance cardiography were measured before the morning dose and at 2, 6, 12, and 24 hours after the morning dose. Heart rate and blood pressure were not markedly altered by any of the H 2 ‐receptor antagonists compared with the findings for placebo. Cimetidine and ranitidine did not markedly alter parameters of systolic time interval and impedance cardiography compared with placebo in contrast to famotidine, which significantly decreased stroke volume, cardiac output, and the Heather Index in impedance cardiography (p < 0.05) and also significantly increased the ratio of the preejection period to the left ventricular ejection time in systolic time interval (p < 0.05) 2 hours after the morning dose. Six hours after administration, most of these alterations could no longer be detected. The observed changes in hemodynamic parameters confirm that famotidine exerts negative effects on cardiac performance, whereas such influences could not be shown for Cimetidine and ranitidine. Clinical Pharmacology and Therapeutics (1990) 48, 302–308; doi: 10.1038/clpt.1990.153