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Teicoplanin pharmacokinetics and bioavailability during peritoneal dialysis
Author(s) -
Brouard Remi J,
Kapusnik Joan E,
Gambertoglio John G,
Schoenfeld Patricia Y,
Sachdeva Meena,
Freel Katherine,
Tozer Thomas N
Publication year - 1989
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1989.89
Subject(s) - pharmacokinetics , bioavailability , continuous ambulatory peritoneal dialysis , volume of distribution , peritoneal dialysis , medicine , teicoplanin , pharmacology , dosing , anesthesia , surgery , vancomycin , biology , bacteria , genetics , staphylococcus aureus
The pharmacokinetics of teicoplanin in serum and dialysate were examined in a crossover study after intravenous and intraperitoneal administration of a 3 mg/kg dose to five anuric patients who were undergoing continuous ambulatory peritoneal dialysis (CAPD). Blood and dialysate samples were obtained for 30 and 15 days, respectively, and were assayed microbiologically. The principal pharmacokinetic parameters after intravenous administration were as follows: total body clearance, 2.76 ± 1.08 ml/min; elimination half‐life, 377 ± 109 hours; volume of distribution at steady state, 1.04 ± 0.18 L/kg. Only 9% ± 6% of the intravenous dose was recovered in the dialysate and the net peritoneal clearance was 0.25 ± 0.21 ml/min. Bioavailability values, which were assessed by use of three methods after intraperitoneal administration and while dialysate was retained in the peritoneal cavity for 5 hours (dwell time), were 0.77 ± 0.21, 0.78 ± 0.05, and 0.76 ± 0.08. Changes in bioavailability with dwell time were also examined. A dosing guide, which accounts for changes in bioavailability with dwell time, is presented. Clinical Pharmacology and Therapeutics (1989) 45 , 674–681; doi: 10.1038/clpt.1989.89