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A model to decrease hepatic blood flow and cardiac output with pressure breathing
Author(s) -
Perkins Mark W,
Dasta Joseph F,
Dehaven Bryan,
Halpern Pinchas,
Downs John B
Publication year - 1989
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1989.71
Subject(s) - continuous positive airway pressure , medicine , heart rate , cardiac output , crossover study , stroke volume , anesthesia , blood pressure , breathing , hematocrit , cardiology , cardiac index , indocyanine green , blood flow , surgery , obstructive sleep apnea , alternative medicine , pathology , placebo
This randomized, controlled, crossover study evaluated the effect of continuous positive airway pressure (CPAP) breathing on hepatic blood flow (HBF) and cardiac output in 10 healthy male subjects. A CPAP mask was placed on the face and the subject breathed at either CPAP 12.5 cm H 2 O or ambient airway pressure. The estimated HBF was calculated as the ratio of indocyanine green plasma clearance to one minus the hematocrit. Cardiac output was measured with Doppler ultrasound. CPAP caused HBF to decrease in 8 of 10 subjects (14.1% ± 15.3%, mean ± SD, p = 0.033) and cardiac index (CI) to decrease in all subjects (14.1% ± 5.7%, p = 0.0001). Stroke volume and respiratory rate were significantly decreased; heart rate was unchanged. These results indicate that CPAP at 12.5 cm H 2 O causes a small, but significant decrease in both HBF and CI. Clinical Pharmacology and Therapeutics (1989) 45, 548–552; doi: 10.1038/clpt.1989.71