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H 2 ‐antagonist inhibition of human neutrophil superoxide anion synthesis
Author(s) -
Zimmerman Jerry,
Millard June
Publication year - 1989
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1989.62
Subject(s) - superoxide , xanthine oxidase , chemistry , pharmacology , allopurinol , cimetidine , in vitro , antagonist , neutrophile , oxidase test , biochemistry , receptor , medicine , enzyme
In the mmol/L concentration range, cimetidine and ranitidine suppress superoxide anion generation by isolated intact human neutrophils. However, at normal pharmacologic concentrations in the µmol/L range, even prolonged exposure of neutrophils to these agents has no demonstrable effect on toxic oxygen species synthesis. In vitro inhibition does not involve neutrophil activation‐densensitization or neutrophil cytotoxicity and is reversible to a great extent by drug washout. In the examination of possible free‐radical scavenging action of these drugs, it was demonstrated that both drugs inhibit superoxide anion production by xanthine oxidase but not by chelated iron. This raises the possibility that these agents may bear structural similarities to oxypyrazolopyrimidines such as allopurinol. Clinical Pharmacology and Therapeutics (1989) 45, 487–494; doi: 10.1038/clpt.1989.62