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Effects of time of dose in relation to food on the bioavailability of Theo‐Dur Sprinkle at steady state in asthmatic children
Author(s) -
Birkett Donald J,
Lines David R,
Kneebone Garry M,
Green Barbara,
Hughes Helen M
Publication year - 1989
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1989.33
Subject(s) - bioavailability , asthma , steady state (chemistry) , relation (database) , pharmacology , physiology , medicine , chemistry , computer science , database
The effects of administration of Theo‐Dur Sprinkle in the fasting state (phase A), 10 minutes before food (phase B), and immediately after food (phase C) were investigated in 12 children with asthma aged 5 to 9 years at steady state. The AUC during the dosing interval was significantly reduced in phases B and C compared with phase A, and bioavailability relative to the fasting state was reduced to 77% ± 15% (range 61% to 104%) in phase B and 70% ± 16% (range 40% to 103%) in phase C. The average plasma theophylline concentration during the dosing interval and C max were also significantly reduced in phases B and C compared with phase A. The morning predose plasma theophylline concentration in phase B was 22% lower than the predose concentration with Theo‐Dur tablets taken 10 minutes before breakfast. The diurnal variation in predose plasma theophylline concentrations was increased from 28% in phase A to 63% in phase C. There was no significant difference in any parameter between administration 10 minutes before food and immediately after food. Clinical Pharmacology and Therapeutics (1989) 45, 305–311; doi: 10.1038/clpt.1989.33