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Effect of yohimbine on blood pressure in patients with depression and orthostatic hypotension induced by clomipramine
Author(s) -
Lacomblez L,
Bensimon G,
Isnard F,
Diquet B,
Lecrubier Y,
Puech A J
Publication year - 1989
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1989.24
Subject(s) - yohimbine , clomipramine , orthostatic vital signs , medicine , blood pressure , anesthesia , antagonist , pharmacology , receptor
Orthostatic hypotension, one of tricyclic antidepressant treatment's side effects, is also a factor in limiting adequate antidepressant dosing. We tested in a double‐blind, crossover, placebo‐controlled study the effect of low doses (4 mg/t.i.d.) of yohimbine in 12 patients with depression with ciomipramine‐induced orthostatic hypotension. Yohimbine, a selective α 2 ‐adrenoceptor antagonist, had a favorable effect in orthostatic hypotension and induced a significant increase in blood pressure. A pharmacodynamic and pharmacokinetic interaction between yohimbine and clomipramine or demethylclomipramine was discussed. Clinical Pharmacology and Therapeutics (1989) 45, 241–251; doi: 10.1038/clpt.1989.24