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Comparison between continuous and intermittent infusion regimens of cimetidine in ulcer patients
Author(s) -
Frank William,
Karlstadt Robyn,
Rockhold Frank,
Palmer Robert,
Malone Maryanne,
Young Michael
Publication year - 1989
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1989.131
Subject(s) - cimetidine , medicine , continuous infusion , regimen , anesthesia , clinical pharmacology , crossover study , pharmacology , alternative medicine , pathology , placebo
The relative effectiveness of intermittent infusions and primed continuous infusions of cimetidine in the maintenance of intragastric pH ≥ 4.0 was evaluated in a double‐blind crossover trial in 26 patients who had active or healed gastroduodenal ulcers. During the intermittent phase, each patient received 300 mg cimetidine intravenously every 6 hours. During the continuous infusion phase, each patient was given a continuous infusion of 37.5 mg cimetidine per hour, preceded by a priming dose of 300 mg cimetidine that was given for 15 minutes. Intragastric pH was monitored continuously. During the last 12 hours of the study, the continuous infusion regimen provided 20% more time in which the pH was less than 4.0 with 25% less medication than did the intermittent infusion regimen. Clinical Pharmacology and Therapeutics (1989) 46 , 234–239; doi: 10.1038/clpt.1989.131