Premium
Pharmacokinetics of N ‐acetylprocainamide in patients profiled with a stable isotope method
Author(s) -
Atkinson Arthur J,
Ruo Tsuen Ih,
Piergies Antoni A,
Breiter Hans C,
Connelly Timothy J,
Sedek Grzegorz S,
Juan David,
Hubler Gary L,
Hsieh AnnMing
Publication year - 1989
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1989.124
Subject(s) - napa , bioavailability , pharmacokinetics , volume of distribution , chemistry , absorption (acoustics) , crossover study , pharmacology , oral administration , renal function , urology , medicine , biochemistry , materials science , pathology , placebo , alternative medicine , composite material
N ‐Acetylprocainamide (NAPA) absorption and disposition were profiled in five patients with ventricular arrhythmias by the simultaneous intravenous administration of NAPA‐ 13 C and oral administration of a 500 mg NAPA hydrochloride tablet. NAPA distribution was modeled with a three compartment mammillary system. The central compartment volume of 14.1 ± 2.6 L (mean ± SD) was similar to expected intravascular space, corrected for NAPA partitioning between erythrocytes and plasma. Other compartment volumes, intercompartmental and nonrenal clearances, and the steady‐state distribution volume of 1.45 ± 0.09 L/kg were similar to normal subject values. The least‐squares estimate of 1.67 for the NAPA renal clearance/creatinine clearance ratio was similar to the value of 1.68 previously reported for functionally anephric patients and showed the expected age‐associated decrease. The oral NAPA dose was 78.0% ± 11.7% absorbed and interindividual variation in NAPA absorption was correlated with fast intercompartmental clearance ( r = 0.89, p = 0.045). Because fast intercompartmental clearance partly reflects splanchnic blood flow, hemodynamic changes may affect NAPA bioavailability, as has been found for procainamide. Clinical Pharmacology and Therapeutics (1989) 46 , 182–189; doi: 10.1038/clpt.1989.124