Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in luman beings

The pharmacokinetics of a single oral dose of 6 mg perphenazine was studied in a group of six slow and six rapid hydroxylators of debrisoquin. Peak serum concentrations of perphenazine were significantly higher in slow hydroxylators than they were in rapid hydroxylators (2.4 ± 0.6 versus 0.7 ± 0.3 nmol/L, p < 0.001). The AUC(0–12) was also higher in slow hydroxylators than it was in rapid hydroxylators (18.5 ± 6.2 versus 4.5 ± 2.5 nmol · L −1 · hr, p < 0.001). The data suggest that the disposition of the antipsychotic drug perphenazine covaries with polymorphic debrisoquin hydroxylation. Clinical Pharmacology and Therapeutics (1989) 46, 78–81; doi: 10.1038/clpt.1989.109