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Decreased myometrial β‐adrenoceptors in women receiving β 2 ‐adrenergic tocolytic therapy: Correlation with lymphocyte β‐adrenoceptors
Author(s) -
Michel Martin C,
Pingsmann Andreas,
Nohlen Manfred,
Siekmann Ulrich,
Brodde OttoErich
Publication year - 1989
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1989.1
Subject(s) - iodocyanopindolol , medicine , lymphocyte , endocrinology , terbutaline , agonist , adrenergic , adrenergic receptor , tocolytic , tocolytic agent , cyclic adenosine monophosphate , receptor , gestation , biology , preterm labor , intrinsic activity , pregnancy , asthma , genetics
We have determined simultaneously the density of β‐adrenoceptors in human myometria (by (‐)‐[ 125 I]iodopindolol binding) derived from 36 women undergoing cesarean section and in the corresponding circulating lymphocytes (by (‐)‐[ 125 I]iodocyanopindolol binding). In myometrial membranes about 80% to 85% of the β‐adrenoceptors were of the β 2 ‐subtype. The density of myometrial and lymphocyte β‐adrenoceptors in women treated with the β 2 ‐ adrenoceptors agonist hexoprenaline to prevent preterm labor was about 65% to 70% lower than that in nontreated women. Concomitantly, in hexoprenaline‐treated women the 10 µmol/L isoproterenol‐evoked increase in lymphocyte cyclic adenosine monophosphate content (as index for lymphocyte β‐adrenoceptor responsiveness) was diminished to a similar extent. Combining all data resulted in a significant positive correlation between myometrial and lymphocyte β‐adrenoceptor densities ( r = 0.7303; n = 36; p < 0.001). It is possible that determination of β‐adrenoceptor function in circulating lymphocytes may be a useful model to monitor myometrial β‐adrenoceptor changes during tocolytic therapy. Clinical Pharmacology and Therapeutics (1989) 45, 1–8; doi: 10.1038/clpt.1989.1