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Renal clearances of oxypurinol and inulin on an isocaloric, low‐protein diet
Author(s) -
Kitt Therese M,
Park Glen D,
Spector Reynold,
Lawton William,
Tsalikian Eva
Publication year - 1988
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1988.95
Subject(s) - inulin , uric acid , low protein diet , creatinine , calorie , renal function , medicine , endocrinology , chemistry , high protein diet , food science , body weight
In previous studies a low‐calorie, low‐protein diet caused a sustained reduction in both oxypurinol and uric acid renal clearances (CL R ). With the hypothesis that the decrease in CL R was due to the low‐protein and not the low‐caloric content of the diet, we studied the CL R of oxypurinol, uric acid, creatinine, and inulin in normal subjects during isocaloric (2600 calories per 70 kg per day), normal‐protein (150 gm per day), and low‐protein (19 gm per day) diets. There were three major findings: (1) the CL R of oxypurinol declined from 26.6 ± 1.8 ml/min on the normal‐protein diet to 13.5 ± 1.4 ml/min on the isocaloric low‐protein diet ( p < 0.05); (2) the CL R of inulin and creatinine fell 14% and 20%, respectively, on the low‐protein diet compared with the normal‐protein diet (both p < 0.05); and (3) there was a diurnal variation in the CL R of oxypurinol. We conclude that the decreased CL R of oxypurinol was the result of the reduced protein content of the diet and the CL R of both inulin and creatinine were decreased on the low‐protein diet. Clinical Pharmacology and Therapeutics (1988) 43 , 681–687; doi: 10.1038/clpt.1988.95