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Pharmacokinetics of high‐dose etoposide
Author(s) -
Newman Edward M,
Doroshow James H,
Forman Stephen J,
Blume Karl G
Publication year - 1988
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1988.73
Subject(s) - pharmacokinetics , etoposide , volume of distribution , pharmacology , medicine , clinical pharmacology , distribution (mathematics) , half life , chemotherapy , mathematics , mathematical analysis
The pharmacokinetics of etoposide at doses of 1 gm/m 2 to 3 gm/m 2 were studied in patients with hematologic malignancies. The noncompartmental systemic clearance, mean residence time, steady‐state volume of distribution, and elimination half‐life were independent of the dose of etoposide, whereas the AUC was proportional to the dose. Comparison of these results with those reported previously indicates that etoposide exhibits linear pharmacokinetics over a thirtyfold range in doses (0.1 to 3 gm/m 2 ). Clinical Pharmacology and Therapeutics (1988) 43, 561–564; doi: 10.1038/clpt.1988.73