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Sore throat pain in the evaluation of mild analgesics
Author(s) -
Schachtel Bernard P,
Fillingim John M,
Thoden William R,
Lane Alberta C,
Baybutt Robert I
Publication year - 1988
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1988.215
Subject(s) - sore throat , ibuprofen , placebo , medicine , throat , acetaminophen , anesthesia , swallowing , clinical pharmacology , surgery , pharmacology , alternative medicine , pathology
A double‐blind, single‐dose parallel study was conducted to assess refinements of a previously tested model for evaluating treatment of sore throat pain. Patients with tonsillopharyngitis randomly received either 400 mg ibuprofen ( n = 39), 1000 mg acetaminophen ( n = 40), or placebo ( n = 41). At hourly intervals for 6 hours the patients reported pain intensity and pain relief on conventional scales and two sensory qualities of throat pain (“swollen throat” and “difficulty swallowing”) on two new visual analog scales. Both active agents were significantly more effective than placebo for all efficacy measurements ( p < 0.01). Ibuprofen, 400 mg, was more effective than acetaminophen, 1000 mg, on all rating scales, conventional and new, at all time points after 2 hours and overall ( p < 0.01). There were no side effects. We conclude that sore throat is a pain model that can be used to discriminate between active medication and placebo, as well as between two effective over‐the‐counter analgesics. Clinical Pharmacology and Therapeutics (1988) 44 , 704–711; doi: 10.1038/clpt.1988.215