Premium
Insulin‐glyburide combination therapy for non‐insulin‐dependent diabetes mellitus: A long‐term double‐blind, placebo‐controlled trial
Author(s) -
Casner Paul R
Publication year - 1988
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1988.199
Subject(s) - medicine , insulin , sulfonylurea , placebo , diabetes mellitus , endocrinology , combination therapy , metabolic control analysis , alternative medicine , pathology
Sixty‐four patients with non‐insulin‐dependent diabetes mellitus were treated with a combination of insulin and oral sulfonylurea therapy in a double‐blind, placebo‐controlled trial during a 12‐month period. Combination therapy lowered fasting glucose levels significantly only at the third and fourth months of treatment. Glycohemoglobin levels were significantly lower than control at 3 and 6 months whereas C‐peptide levels were significantly increased at 3 and 9 months. Responders exhibited as much as a 50% reduction in total insulin dose compared with nonresponders or control subjects. These results suggest that combination therapy affords transient metabolic improvement in certain patients with non‐insulin‐dependent diabetes. Improvement in fasting glucose levels appears to be mediated by enhanced insulin secretion. Combination therapy may increase the cost of treatment by nearly 50% and appears warranted only in selected patients. Clinical Pharmacology and Therapeutics (1988) 44, 594–603; doi: 10.1038/clpt.1988.199