Premium
The theophylline‐enoxacin interaction: I. Effect of enoxacin dose size on theophylline disposition
Author(s) -
Rogge Mark C,
Solomon William R,
Sedman Allen J,
Welling Peter G,
Toothaker Roger D,
Wagner John G
Publication year - 1988
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1988.197
Subject(s) - enoxacin , theophylline , pharmacology , pharmacokinetics , drug interaction , chemistry , urine , crossover study , bronchodilator , medicine , antibiotics , biochemistry , asthma , alternative medicine , pathology , norfloxacin , ciprofloxacin , placebo
Theophylline interacts pharmacokinetically with a variety of other drugs. Recently enoxacin was found to change theophylline's disposition. In a four‐subject, four‐way crossover study enoxacin was administered every 12 hours at four levels (0, 25, 100, and 400 mg) for 14 doses. With the ninth dose of enoxacin, 200 mg theophylline was coadministered. Blood and urine samples were assayed by sensitive and specific assays for the parent drugs and their metabolites. Significant reduction in the formation of theophylline's three major metabolites occurred on coadministration of enoxacin. At the 400 mg dose level, enoxacin caused a threefold decrease in theophylline's plasma clearance, a fourfold decrease in the urinary recovery of 3‐methylxanthine and 1, 3‐dimethylurate, and a threefold decrease in the recovery of 1‐methylurate. Clinical Pharmacology and Therapeutics (1988) 44, 579–587; doi: 10.1038/clpt.1988.197