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Age does not alter human vascular and nonvascular β 2 ‐adrenergic responses to isoproterenol
Author(s) -
Klein Catherine,
Hiatt William R,
Gerber John G,
Nies Alan S
Publication year - 1988
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1988.196
Subject(s) - adrenergic , medicine , plethysmograph , endocrinology , vascular resistance , peripheral resistance , peripheral , cardiac output , hemodynamics , receptor
β‐Adrenoceptor‐mediated functions appear to diminish with aging, but the exact scope of these changes is unknown, because most studies have been limited to β 1 ‐adrenergic cardiac phenomena. To evaluate both a vascular and a nonvascular β 2 ‐adrenergic response in the aged, we have studied 12 healthy elderly and 12 healthy young subjects infused with increasing doses of isoproterenol and compared the change in peripheral vascular resistance, measured by venous occlusion plethysmography, and insulin release. In both groups vascular resistance fell and insulin concentrations increased. These changes were equivalent in both groups, and we therefore infer no significant decline in either of these β 2 ‐adrenergic functions in the elderly. Clinical Pharmacology and Therapeutics (1988) 44, 573–578; doi: 10.1038/clpt.1988.196