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Polymorphic debrisoquin hydroxylation in 757 Swedish subjects
Author(s) -
Steiner Eugen,
Bertilsson Leif,
Säwe Juliette,
Bertling Ingegärd,
Sjöqvist Folke
Publication year - 1988
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1988.176
Subject(s) - urine , hydroxylation , repeatability , allele frequency , medicine , biology , allele , genetics , chemistry , chromatography , biochemistry , enzyme , gene
The metabolic ratios (MRs) between debrisoquin and 4‐hydroxydebrisoquin in urine after a single oral dose of 10 mg debrisoquin were bimodally distributed in 757 healthy, white Swedish volunteers. Forty‐one subjects (5.4%) had an MR >12.6 and were classified as slow debrisoquin hydroxylators. The MR was reproducible in urine stored at + 8° C for 1 week and at − 20° C over a period of 5 yers. Collection intervals of 6 or 12 hours gave the same MR. Intraindividual repeatability of the debrisoquin phenotyping test was established in 37 subjects examined twice at least 2 weeks apart. The calculated frequency of the single allele that is believed to control deficient debrisoquin hydroxylation is similar among white Swedish people, as among other white groups examined so far; however, it is significantly different from the frequency in certain Oriental groups. Detailed comparisons of the prevalence of slow debrisoquin hydroxylation in different ethnic groups are not possible due to shortcomings in current epidemiologie techniques used (small materials, the location of the antimode distinguishing rapid and slow hydroxylators unknown, and family studies missing). Clinical Pharmacology and Therapeutics (1988) 44, 431–435; doi: 10.1038/clpt.1988.176