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Histamine and histamine receptor antagonists in splanchnic compartments in schistosomal portal hypertension
Author(s) -
ElGendi M A,
Nassar Sara H,
ElBassiouni E A
Publication year - 1988
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1988.170
Subject(s) - histamine , cimetidine , metiamide , medicine , splanchnic circulation , antagonist , portal hypertension , portal venous pressure , histamine h2 receptor , splanchnic , pharmacology , histamine receptor , receptor , anesthesia , gastroenterology , endocrinology , hemodynamics , cirrhosis
The type and distribution of histamine receptors in the portal circulation were studied in patients with schistosomal hypertension. At laparotomy, the umbilical, left gastric, splenic, and superior mesenteric veins were cannulated. Blood samples were drawn from the systemic circulation and from each vein for histamine assay. Portal pressures were then estimated in each vein. One group of patients received local injections of pheniramine p ‐aminosalicylate (H 1 ‐antagonist) in the four cannulated veins simultaneously. A second group received cimetidine (H 2 ‐antagonist), and a third group received a mixture of both drugs. Reestimation of portal pressures indicated that all treatments produced a significant drop in pressure in the four compartments. The highest drop was in the splenic vein after the H 1 ‐antagonist and in the gastric vein after the H 2 ‐antagonist. The histamine level was somewhat higher in the splenic compartment. These results suggest that both H 1 ‐ and H 2 ‐receptors are present in the four portal compartments, but their distribution may not be uniform. Clinical Pharmacology and Therapeutics (1988) 44, 396–399; doi: 10.1038/clpt.1988.170