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The effect of clonidine on the cessation of cigarette smoking
Author(s) -
Davison Richard,
Kaplan Kerry,
Fintel Dan,
Parker Michele,
Anderson Linda,
Haring Olga
Publication year - 1988
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1988.148
Subject(s) - clonidine , discontinuation , medicine , placebo , abstinence , smoking cessation , anesthesia , significant difference , psychiatry , alternative medicine , pathology
The effect of clonidine on smoking cessation was studied by randomly assigning 186 smokers in a double‐blind fashion to either placebo or clonidine. Abstinence from smoking was reported more frequently by subjects receiving clonidine, but the difference was statistically significant only at the end of the first week (34.4% vs 21.5%; p < 0.05). Bothersome side effects were common and resulted in the early discontinuation of the study medication by 23 of the subjects taking clonidine and eight taking placebo ( p < 0.05). Although this study did not demonstrate a significant effect of clonidine on smoking cessation, a beneficial trend was detected and therefore further trials with transcutaneous delivery of this agent in combination with behavior modification techniques are warranted. Clinical Pharmacology and Therapeutics (1988) 44 , 265–267; doi: 10.1038/clpt.1988.148