Premium
Effects of prednisone, aspirin, and acetaminophen on an in vivo biologic response to interferon in humans
Author(s) -
Witter Frank R,
Woods Amina S,
Griffin M Diane,
Smith Craig R,
Nadler Paul,
Lietman Paul S
Publication year - 1988
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1988.143
Subject(s) - aspirin , prednisone , acetaminophen , medicine , pharmacology , interferon , vesicular stomatitis virus , pharmacokinetics , immunology , virus
In healthy volunteers receiving a single intramuscular dose of 18 × 10 6 U interferon alone or after 24 hours of an 8‐day course of prednisone (40 mg/day), aspirin (650 mg every 4 hours), or acetaminophen (650 mg every 4 hours), the magnitude of the biologic response to interferon was quantified by measuring the time course of the induction of 2′‐5′‐oligoadenylate synthetase and resistance to vesicular stomatitis virus infection in human peripheral blood mononuclear cells. Prednisone decreased the AUC of 2′‐5′‐oligoadenylate synthetase activity ( p < 0.05), whereas administration of aspirin or acetaminophen did not affect this biologic response. No measurable effect was seen during administration of prednisone, aspirin, or acetaminophen on the duration or intensity of vesicular stomatitis virus yield reduction. The side effects seen with interferon administration at the dose tested were not altered in a clinically meaningful manner by prednisone, aspirin, or acetaminophen. Clinical Pharmacology and Therapeutics (1988) 44 , 239–243; doi: 10.1038/clpt.1988.143