Premium
Effects of iloprost, a prostacyclin analog derivative, on renal plasma flow, renal function, and renin‐aldosterone system in humans
Author(s) -
Angeli Paolo,
Gatta Angelo,
Caregaro Lorenza,
Me Francesca,
Sacerdoti David,
Merkel Carlo,
Visoná Adriana,
Lusiani Luigi,
Pagnan Antonio
Publication year - 1988
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1988.139
Subject(s) - iloprost , filtration fraction , renal blood flow , renal function , plasma renin activity , prostacyclin , renal sodium reabsorption , medicine , fractional excretion of sodium , endocrinology , chemistry , reabsorption , effective renal plasma flow , kidney , blood pressure , renin–angiotensin system
The effects of iloprost, a stable analog derivative of prostacyclin, on heart rate, blood pressure, renal plasma flow (RPF), glomerular filtration rate, filtration fraction, urine flow, fractional excretion of sodium (FE Na ), proximal fractional sodium reabsorption (PFR Na ), fractional sodium resorption at the ascending limb of Henle's loop (HFR Na ), plasma renin activity (PRA), and plasma aldosterone concentration (PA) were evaluated in patients with peripheral vascular disease and normal renal function. In 10 patients the drug was administered intravenously for 6 hours daily for 6 days at a rate of 1 ng/kg/min. In 7 patients iloprost was also administered at a dose of 2 ng/kg/min for the same time. There was no significant change in heart rate and blood pressure at both iloprost doses. At the dose of 1 ng/kg/min the drug had no effect on renal hemodynamics and function, PRA, and PA. At the dose of 2 ng/kg/min iloprost significantly increased RPF ( p < 0.025) and FE Na ( p < 0.025) and significantly decreased HFR Na ( p < 0.025) without affecting glomerular filtration rate, filtration fraction, urine flow, PFR Na , PRA, and PA. No correlation was found between the increase in RPF and FE Na ( r = 0.01). We conclude that at a dose of 2 ng/kg/min, but not 1 ng/kg/min, iloprost has a natriuretic effect secondary to inhibition of sodium reabsorption at the ascending limb of the Henle's loop and not related to the renal hemodynamic effect. Clinical Pharmacology and Therapeutics (1988) 44 , 211–216; doi: 10.1038/clpt.1988.139