The effect of trimoprostil (trimethyldesoxy prostaglandin E 2 ) on the intrauterine pressure in women

Prostaglandin E 2 is uterotonic. Trimoprostil, a prostaglandin E 2 analog, is a gastric antisecretory and cytoprotective agent. The effects of single doses of 0, 0.125, 0.75, and 3.0 mg trimoprostil on intrauterine pressure were measured in a double‐blind, crossover study in eight surgically sterile women. The 3 mg dose was not tolerated because of abdominal cramps. The other doses caused a dose‐related increase in resting uterine tone and peak pressure with peak effect occurring between 30 and 60 minutes after administration with a duration of about 120 minutes. No effects on the frequency of uterine contractions occurred. Peak mean tone increased from 11.0 to 71.2 mm Hg ( p < 0.01) and peak pressure from 24.6 to 125.1 mm Hg ( p < 0.01) after placebo compared with the 1.5 mg dose. Adverse reactions included abdominal pain that correlated with an increase in intrauterine pressure and tone. Clinical Pharmacology and Therapeutics (1988) 44 , 179–185; doi: 10.1038/clpt.1988.134