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Trough levels and concentration time curves of cyclosporine in patients undergoing renal transplantation
Author(s) -
Frey Felix J,
Horber Fritz F,
Frey Brigitte M
Publication year - 1988
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1988.11
Subject(s) - trough (economics) , medicine , high performance liquid chromatography , trough level , trough concentration , transplantation , clinical pharmacology , oral administration , pharmacokinetics , serum concentration , renal transplant , urology , predictive value , pharmacology , chemistry , chromatography , tacrolimus , economics , macroeconomics
We determined the AUC of cyclosporine (24 hours) nonspecifically by RIA and specifically by HPLC after an oral and an intravenous dose of cyclosporine in 58 patients undergoing renal transplantation. The RIA/HPLC concentration ratio of cyclosporine changed continuously during the first 12 hours after administration. The ratio was higher after oral than after intravenous administration and varied from patient to patient. The predictive value of trough levels for the corresponding AUCs was better when trough levels were assessed 24 than 12 hours after administration. Trough levels assessed by RIA poorly predicted AUCs measured specifically by HPLC. Therefore if, in the future, therapeutic cyclosporine monitoring has to be improved, trough levels should be assessed 24 hours after the last dose by means of a specific HPLC method. Clinical Pharmacology and Therapeutics (1988) 43, 55–62; doi: 10.1038/clpt.1988.11