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Brachial artery hemodynamic response to acute converting enzyme inhibition by enalaprilat in essential hypertension
Author(s) -
Simon Alain C,
Chau Nguyen P,
Levenson Jaime
Publication year - 1988
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1988.10
Subject(s) - enalaprilat , brachial artery , blood pressure , medicine , hemodynamics , saline , blood flow , cardiology , enalapril , anesthesia , pulse pressure , angiotensin converting enzyme
To assess the vascular involvement of renin‐angiotensin system inhibition in human hypertension, acute effects of intravenous enalaprilat on brachial artery diameter, blood flow, and blood velocity were investigated in hypertensive patients by pulsed Doppler technique and compared with effects of saline vehicle. Compared with saline vehicle, enalaprilat reduced blood pressure (P < 0.001) and increased brachial arterial diameter (P < 0.01) and brachial blood flow (P < 0.01). Enalaprilat effect on arterial pulse pressure was dependent on preinjection pulse pressure (r = −0.76; P < 0.001), but its effect on mean blood pressure was not dependent on preinjection mean blood pressure. On the other hand, enalaprilat effect on arterial blood flow was negatively correlated with preinjection blood pressure (r = − 0.64; P < 0.02). The findings point to different responses of large and small arteries to intravenous enalaprilat. Clinical Pharmacology and Therapeutics (1988) 43, 49–54; doi: 10.1038/clpt.1988.10