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Pharmacokinetics of synthetic atrial natriuretic peptides in normal men
Author(s) -
Biollaz J,
Callahan L T,
Nussberger J,
Waeber B,
Gomez H J,
Blaine E H,
Brunner H R
Publication year - 1987
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1987.94
Subject(s) - atrial natriuretic peptide , medicine , endocrinology , pharmacokinetics , hemodynamics , chemistry , volume of distribution , excretion , peptide hormone , hormone
The kinetics of atrial natriuretic peptides (ANP) and the kinetic profile of their effect on blood pressure and renal hemodynamic and electrolyte excretion were investigated in 20 salt‐loaded healthy volunteers during and after constant rate infusion. At steady state, mean plasma concentrations of ANP were measured at 210, 430, and 2990 pg/ml and mean systemic clearance was 2.6, 2.5, and 1.7 L/min for ANP infusion rates of 0.5, 1, and 5 μg/min, respectively, which corresponds to the clearance rate of other vasoactive peptide hormones. The apparent volume of distribution averaged 17 L and the mean half‐life was 4.5 minutes. ANP induced dose‐related effects on systemic and renal hemodynamic, as well as urinary electrolyte excretion, albeit with a time lag between onset and full effect. Clinical Pharmacology and Therapeutics (1987) 41 , 671–677; doi: 10.1038/clpt.1987.94