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Ticlopidine‐theophylline interaction
Author(s) -
Colli Agostino,
Buccino Guglielmo,
Cocciolo Massimo,
Parravicini Roberto,
Elli Gian Maria,
Scaltrini Giancarlo
Publication year - 1987
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1987.39
Subject(s) - theophylline , pharmacokinetics , ticlopidine , bronchodilator , pharmacology , drug interaction , medicine , clinical pharmacology , drug , asthma , aspirin , clopidogrel
Ticlopidine, a new antithrombotic agent, and theophylline, a widely used bronchodilator drug, are both almost completely metabolized in the liver. To evaluate an interaction between these two drugs, we studied theophylline pharmacokinetics before, after 10 days of ticlopidine administration, and 1 month later in 10 healthy volunteers. We found a highly significant increase in the theophylline elimination half‐life (P < 0.001) and a comparable reduction in its total plasma clearance (P < 0.001) after ticlopidine treatment. Pharmacokinetic parameters returned to initial values within 30 days after ticlopidine withdrawal. Moreover, no changes in theophylline pharmacokinetic parameters were observed 3 months later, before and after 10 days of placebo administration. Our results seem to exclude direct liver toxicity and may suggest a reversible inhibition of the liver metabolic capacity of theophylline. Clinical Pharmacology and Therapeutics (1987) 41, 358–362; doi: 10.1038/clpt.1987.39