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Interactions between 1,25‐dihydroxyvitamin D 3 and vitamin D 2 : Effects of pharmacologic doses in normal individuals
Author(s) -
Hui Rina,
Trube Angelika,
Lissner Dianne,
Wilkinson Margaret R,
Mason Rebecca S,
Posen Solomon
Publication year - 1987
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1987.212
Subject(s) - endocrinology , osteocalcin , vitamin d and neurology , medicine , vitamin , concomitant , serum concentration , chemistry , alkaline phosphatase , biochemistry , enzyme
To determine whether the administration of 1,25‐dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ) affects the conversion of a pharmacologic dose of vitamin D 2 to 25‐hydroxyvitamin D (25OHD), 20 normal subjects received two separate doses of vitamin D 2 —one with and the other without the concomitant administration of 1,25(OH) 2 D 3 . Serum 1,25(OH) 2 D rose in response to 1,25(OH) 2 D 3 administration and fell when vitamin D 2 was given alone. Serum osteocalcin rose in response to 1,25(OH) 2 D 3 administration. Serum 25OHD rose in response to vitamin D 2 administration regardless of whether the subjects also received 1,25(OH) 2 D 3 . The data from this study in humans support the suggestion that the effects of 1,25(OH) 2 D 3 on serum 25OHD concentrations are mediated through mechanisms other than impairment of production. Clinical Pharmacology and Therapeutics (1987) 42 , 641–645; doi: 10.1038/clpt.1987.212