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The additive analgesic efficacy of acetaminophen,1000 mg, and codeine, 60 mg, in dental pain
Author(s) -
Bentley Kenneth C,
Head Timothy W
Publication year - 1987
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1987.211
Subject(s) - codeine , acetaminophen , analgesic , medicine , anesthesia , pharmacology , morphine
In a double‐blind, randomized, single‐dose trial the analgesic contribution of acetaminophen, 1000 mg, and codeine, 60 mg, was determined. The study was a 2 × 2 factorial experiment in which 120 patients suffering from pain as a result of oral surgery rated their pain intensity and pain relief for up to 5 hours after a single dose of one of: 1000 mg acetaminophen, 60 mg codeine, 1000 mg acetaminophen plus 60 mg codeine, or placebo. The factorial analysis showed that both 1000 mg acetaminophen and 60 mg codeine made a statistically significant (P < 0.05) contribution to the analgesic effectiveness of the combination on all measures of efficacy (sum of pain intensity differences, largest pain intensity difference, total pain relief, largest pain relief, and time to remedication). The incidence of adverse effects did not appear to differ among the treatments, including placebo. Clinical Pharmacology and Therapeutics (1987) 42 , 634–640; doi: 10.1038/clpt.1987.211