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Effect of naltrexone on ethanol‐provoked flushing in oriental and white subjects
Author(s) -
Wilkin Jonathan K,
Hazelrigg Eric J
Publication year - 1987
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1987.200
Subject(s) - naltrexone , flushing , placebo , laser doppler velocimetry , medicine , nausea , anesthesia , endocrinology , blood flow , antagonist , pathology , receptor , alternative medicine
The effect of naltrexone vs. placebo on alcohol‐provoked flushing was studied in 20 healthy subjects of Oriental ancestry and 20 healthy white subjects. The intensity of the flushing reactions was assessed by two independent methods, the cutaneous perfusion index by laser Doppler velocimetry and the change in malar thermal circulation index by telethermometry. No effect of naltrexone on alcohol‐provoked flushing was detected with either method in either racial group. The incidence of abdominal discomfort and nausea associated with naltrexone treatment was much greater among Orientals than whites. Clinical Pharmacology and Therapeutics (1987) 42, 582–587; doi: 10.1038/clpt.1987.200