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Absorption studies of the H 2 ‐blocker nizatidine
Author(s) -
Knadler Mary Pat,
Bergstrom Richard F,
Callaghan John T,
Obermeyer Boyd D,
Rubin Alan
Publication year - 1987
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1987.190
Subject(s) - bioavailability , pharmacology , clinical pharmacology , placebo , activated charcoal , medicine , oral administration , absorption (acoustics) , ingestion , chemistry , physics , alternative medicine , organic chemistry , pathology , adsorption , acoustics
The absolute and relative bioavailability of nizatidine, an H 2 ‐blocker, was studied in healthy male volunteers. The absolute oral bioavailability, relative to that after intravenous administration, was 98% ± 14%. The bioavailability of single and multiple oral doses of 150 mg nizatidine was unaffected by concurrent food ingestion; nizatidine may be administered either with or without food. The relative bioavailability of nizatidine was compared when given simultaneously with placebo or Gelusil, 30 minutes after propantheline, or 60 minutes before activated charcoal. Gelusil reduced the amount of nizatidine absorbed by about 10%, charcoal reduced it by about 30%, and propantheline did not affect it. Clinical Pharmacology and Therapeutics (1987) 42, 514–520; doi: 10.1038/clpt.1987.190