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Biliary excretion of intravenous [ 14 C] omeprazole in humans
Author(s) -
Lind Tore,
Andersson Tommy,
Skanberg Inger,
Olbe Lars
Publication year - 1987
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1987.188
Subject(s) - omeprazole , excretion , medicine , gastroenterology , stomach , chemistry , pharmacology
We have studied the biliary excretion of [ 14 C] omeprazole in humans. The study was performed in eight healthy subjects and the technique used was based on multiple marker dilution principles with doublelumen tubes placed in both the stomach and intestine. The results obtained show a 16% biliary excretion of [ 14 C] omeprazole. These data suggest a minimal “spillover” of omeprazole from the gastric mucosa into the gastric lumen in humans. The results also agree with previous data of the fecal recovery of radiolabeled omeprazole that suggest that the fecal excretion of intravenous omeprazole in humans is entirely accounted for by biliary excretion. Clinical Pharmacology and Therapeutics (1987) 42, 504–508; doi: 10.1038/clpt.1987.188