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The effect of sorbitol and activated charcoal on serum theophylline concentrations after slow‐release theophylline
Author(s) -
Goldberg Mark J,
Spector Reynold,
Park Glen D,
Johnson George F,
Roberts Pamela
Publication year - 1987
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1987.18
Subject(s) - theophylline , activated charcoal , sorbitol , charcoal , ingestion , chemistry , regimen , crossover study , pharmacology , antidote , zoology , medicine , toxicity , food science , biochemistry , adsorption , biology , placebo , alternative medicine , organic chemistry , pathology
The effect of the addition of sorbitol to an oral regimen of multiple doses of activated charcoal on serum theophylline concentrations was studied after the ingestion of slow‐release theophylline in nine healthy male volunteers. At 6, 7, 8, 10, and 12 hours after Theo‐24 (1200 mg/70 kg) ingestion, each subject received, in a randomized crossover design, either 300 ml water, 20 gm activated charcoal in water, or 20 gm activated charcoal in water plus 75 ml 70% sorbitol at 6 and 8 hours only. The serum AUCs from 6 to 30 hours after Theo‐24 ingestion during the water, charcoal, and charcoal plus sorbitol phases were 305 ± 16, 113 ± 6, and 85 ± 10 mg‐hr/L (mean ± SE), respectively. We conclude that the addition of sorbitol to an oral regimen of multiple doses of activated charcoal decreased the serum theophylline concentrations after therapeutic doses of slow‐release theophylline to a significantly greater extent than did the activated charcoal regimen alone. Clinical Pharmacology and Therapeutics (1987) 41, 108–111; doi: 10.1038/clpt.1987.18