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Pharmacokinetics of rimantadine hydrochloride in patients with chronic liver disease
Author(s) -
Wills Robert J,
Belshe Robert,
Tomlinsin Diana,
De Grazia Francis,
Lin Amy,
Wells Sally,
Milazzo Jack,
Berry Carol
Publication year - 1987
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1987.176
Subject(s) - rimantadine , pharmacokinetics , medicine , volume of distribution , liver disease , urine , chronic liver disease , clinical pharmacology , gastroenterology , pharmacology , immunology , cirrhosis , influenza a virus , virus
Six patients with chronic liver disease and six sex‐, age (± 5 years)‐, and weight (± 5 kg)‐matched healthy control subjects received a single dose of two 100 mg tablets rimantadine HCl. Eight additional patients with chronic liver disease who were not matched to healthy subjects received a single dose of two 100 mg tablets of rimantadine HCl. Blood and urine samples were collected and rimantadine concentrations were determined by a GCMS method. The values for maximum plasma concentration, AUC, elimination half‐life, and renal clearance were not significantly different between patients and control subjects, independent of the statistical analyses (parametric and nonparametric) used. The mean apparent elimination half‐life, volume of distribution, and total clearance in the matched patients with liver disease were 32 hours, 24 L/kg, and 676 ml/min, respectively. Renal clearance and the amount excreted in the urine unchanged were 63 ml/min and 10%, respectively. In conclusion, rimantadine pharmacokinetics were not appreciably altered in patients with less severe chronic liver disease. Clinical Pharmacology and Therapeutics (1987) 42, 449–454; doi: 10.1038/clpt.1987.176