z-logo
Premium
Evaluation of isradipine (PN 200‐110) in mild to moderate hypertension
Author(s) -
Winer Nathaniel,
ThysJacobs Susan,
Kumar Raminder,
Davidson Warren D,
Grayson Martha,
Harris Calvin,
Walker Deborah,
Itskovitz Harold,
Gonasun Leonard
Publication year - 1987
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1987.175
Subject(s) - isradipine , supine position , medicine , placebo , blood pressure , anesthesia , urology , dihydropyridine , calcium , alternative medicine , pathology
The efficacy and safety of isradipine (PN 200‐110), a new dihydropyridine calcium antagonist, was evaluated in 87 hypertensive patients in a placebo‐controlled, double‐blind, randomized multicenter trial. After a 3‐week single‐blind washout phase, isradipine (or matching placebo) was administered for 4 weeks, beginning at 2.5 mg b.i.d. with increments of 2.5 mg b.i.d. at weekly intervals if supine diastolic blood pressure remained ≥90 mm Hg. At the end of 1 week average supine blood pressure in the isradipine group (n = 45) fell from a baseline of 156 ± 13/104 ± 4 mm Hg to 146 ± 14/97 ± 7 mm Hg. By week 4 blood pressure was reduced by 19/14 mm Hg compared with 4/5 mm Hg in the placebo group (P < 0.001 between groups). Supine and standing pulse rates were slightly increased initially with isradipine therapy but returned to baseline with increasing isradipine doses. Blood pressure responses at week 4 were good or excellent (supine diastolic ≤90 mm Hg or ≥10 mm Hg decrease from baseline) in 87% of isradipine‐treated patients and in 26% of placebo‐treated patients. Headache, edema, abdominal discomfort, and constipation occurred slightly more frequently in isradipine‐treated patients than in placebo‐treated control subjects. The results indicate that isradipine, administered as monotherapy in doses of 2.5 to 10 mg b.i.d., is safe and effective in patients with mild to moderate essential hypertension. Clinical Pharmacology and Therapeutics (1987) 42, 442–448; doi: 10.1038/clpt.1987.175

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here