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Effect of high‐dose etodolac on renal function
Author(s) -
Brater D Craig,
BrownCartwright Debbie,
Anderson Shirley A,
Uaamnuichai Mana
Publication year - 1987
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1987.148
Subject(s) - etodolac , renal function , inulin , clinical pharmacology , pharmacology , medicine , renal physiology , chemistry , urinary system , urology , biochemistry
Previous studies from our laboratory have demonstrated transient effects on renal function by etodolac, 200 mg b.i.d. The current study assessed the effects of a larger dose of etodolac (500 mg b.i.d.) to explore the time course of its renal effects and to determine whether the transient effect would become more prolonged with a larger dose. We studied 10 normal subjects and nine patients with renal insufficiency, examining the effects of the first 500 mg dose of etodolac as well as 4 days of b.i.d. administration. In both groups, etodolac transiently decreased fractional excretions of sodium and chloride and urinary prostaglandin E 2 . In patients, etodolac also transiently decreased inulin and para‐aminohippuric acid clearances and urinary 6‐keto‐prostaglandin F 1α . Chronic administration caused no changes in renal function in either group. In summary, in this relatively small group of patients, high‐dose etodolac caused only transient, fully reversible effects on renal function, the cumulative effect of which was negligible. Clinical Pharmacology and Therapeutics (1987) 42, 283–289; doi: 10.1038/clpt.1987.148