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Effect of structured dietary fiber on bioavailability of amoxicillin
Author(s) -
Lutz Mariane,
Espinoza Julio,
Arancibia Aquiles,
Araya Magdalena,
Pacheco Isoida,
Brunser Oscar
Publication year - 1987
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1987.135
Subject(s) - bioavailability , pharmacokinetics , absorption (acoustics) , chemistry , elimination rate constant , lag time , absorption efficiency , zoology , dietary fiber , amoxicillin , absorption rate , oral administration , pharmacology , food science , medicine , chromatography , antibiotics , biochemistry , biology , volume of distribution , physics , acoustics , biological system
The effect of structured dietary fiber on the bioavailability of amoxicillin (AMX) was evaluated. Ten healthy volunteers ingested one of two isocaloric, isonitrogenous diets providing 7.8 gm/day (diet I) and 36.2 gm/day (diet II) of structured fiber for 3 days. Then they ingested one tablet (500 mg) AMX after breakfast. The other diet was administered for an additional 3 days and the study was repeated. Plasma and urinary AMX concentrations were measured at 9 and 24 hours, respectively, by a microbiologic technique. An open one‐compartment model was used for pharmacokinetic analysis. AMX was absorbed more slowly when ingested with diet I than with diet II: the absorption rate constant was 1.04 ± 0.37 and 1.75 ± 0.75 (P < 0.05); lag time for absorption was 0.34 ± 0.13 hours and 0.29 ± 0.11 hours (P < 0.05). The first‐order rate constant and elimination half‐life were similar. Bioavailability was higher with diet I: the AUC was 12.17 ± 3.04 vs. 9.65 ± 2.64 µg/ml/hr with diet II (P < 0.05). A higher content of dietary fiber increased AMX absorption rate and decreased the amount of drug absorbed. Clinical Pharmacology and Therapeutics (1987) 42, 220–224; doi: 10.1038/clpt.1987.135