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Hydrochlorothiazide‐amiloride causes excessive urinary zinc excretion
Author(s) -
Golik Ahuva,
Modai David,
Weissgarten Joshua,
Cohen Natan,
Averbukh Zhan,
Sigler Erika,
Zaidenstein Ronit,
Shaked Uri
Publication year - 1987
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1987.105
Subject(s) - hydrochlorothiazide , amiloride , zinc , excretion , diuretic , clinical pharmacology , urinary system , endocrinology , medicine , pharmacology , urology , chemistry , sodium , blood pressure , organic chemistry
Serum zinc levels and urinary zinc excretion were compared in 15 patients with essential hypertension taking chronically a combination of hydrochlorothiazide and amiloride as monotherapy, eight patients maintained with hydrochlorothiazide alone, and eight control subjects. Serum zinc values were statistically comparable in all three groups. However, urinary zinc excretion was abnormally elevated in the two patient groups. In the dosage used, amiloride did not have a zinc‐sparing effect. Clinical Pharmacology and Therapeutics (1987) 42, 42–44; doi: 10.1038/clpt.1987.105